Endocrine Abstracts

Background: Aneurismal bone cysts (ABCs) are rare benign tumours of the bone that, similar to the giant cell tumours (GCTBs) of the bone, contain osteoclast-like giant cells. Standard therapeutic options include different surgical approaches and/or radiotherapy. However, in selected cases, other therapeutic options are needed. Denosumab, a human monoclonal antibody to receptor activator nuclear factor kappa B ligand (RANKL) has been approved for the treatment of giant cells tu...

Background: Type 1 diabetes mellitus (T1DM) is caused by destruction of pancreatic beta cells. Children and adolescents with type 1 diabetes have an increased risk of developing other autoimmune diseases, most commonly autoimmune thyroiditis and celiac disease.Objectives: To examine the frequency of individual human leukocyte antigen (HLA) alleles in people with T1DM and associated autoimmune (AI) diseases of the thyroid, digestive system, and skin, and ...

Background: According to the World Health Organization, there are approximately 650 million obese adults worldwide. In Croatia almost 2/3 (65%) of adults are overweight (42%) or obese (23%), with a growing tendency both in adults and children. The surgical procedures performed to manage obesity are referred to as metabolic or “bariatric” surgery. Candidates for a bariatric surgical procedure include obese patients with a BMI ≥ 40 kg/m2(obesity class ...